Biology Seminar Speaker

Monday, October 24, 2022 at 3:00pm to 4:00pm

Schrenk Hall, 126 400 West 11th Street 105 Schrenk Hall

Dr. Pam Brown from University of Missouri Columbia Medical School will make a presentation titled "The ChvG/ChvI signaling pathway has an ancestral role during cell wall stress in Alphaproteobacteria" 

Soil dwelling bacteria reside in changing environments requiring them to frequently adapt to stressful conditions to ensure survival. The bacterial envelope provides structural integrity and protection against osmotic stress and turgor pressure imposed by the environment. While the mechanisms of cell membrane and cell wall biogenesis have been extensively studied, our understanding of how diverse microbes respond to cell envelope and cell wall stress to increase their fitness remains limited. In this work, we identify ChvG-ChvI regulon as an envelope stress response system that confers protection under cell wall stress conditions in the bacterial plant pathogen Agrobacterium tumefaciens. This is a new function for the well-characterized ChvG-ChvI pathway which is also acid induced and promotes plant host invasion. Our results suggest that the ChvG-ChvI pathway has a broadly conserved role in protecting Alphaproteobacterial cells from extracellular stress and a more specific role in response to acid stress and promoting plant-microbe interactions.

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College of Arts, Sciences, and Education, Biological Sciences

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