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VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
X-WR-CALNAME:Final Doctoral Defense for Hsin-Yin Chuang
X-WR-TIMEZONE:Central Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260605T223820Z
UID:tag:localist.com\,2008:EventInstance_52770539350016
DTSTART:20260612T140000Z
DTEND:20260612T160000Z
DESCRIPTION:Hsin-Yin Chuang\, a doctoral candidate in chemical engineering\
 , will defend their dissertation titled “Adaptable Upa-Mediated Dendrime
 r Gel Nanoparticles for Therapeutic and Diagnostic Applications in Cancer 
 and Atherosclerosis” Their advisor\, Dr. Hu Yang is an adjunct professor
  in chemical and biochemical engineering. The dissertation abstract is pro
 vided below.\n\nThis dissertation presents the development of adaptive uro
 kinase-type plasminogen activator (uPA)-mediated dendrimer nanoparticles f
 or targeted therapy and diagnosis of cancer and atherosclerosis. These dis
 eases share common features of inflammation and dysregulated cell death\, 
 yet current treatments lack precision and early detection capability. In t
 he first study\, a dual-targeted dendrimer gel nanoparticle (GDP-uPA/GTI) 
 was designed to target uPAR and ribonucleotide reductase R2 in triple-nega
 tive breast cancer (TNBC). GDP-uPA/GTI effectively suppressed R2\, induced
  apoptosis\, necrosis\, and cell-cycle arrest\, and reduced tumor growth w
 ithout toxicity. The second study expands this strategy to atherosclerosis
  through a uPA-functionalized\, rapamycin-loaded dendrimer nanoparticle (G
 5PM-uPA/RA). This platform accumulated in plaques of Ldlr−/−mice\, sup
 pressed pro-inflammatory cytokines\, reduced apoptosis and necrotic core s
 ize\, and increased fibrous cap thickness\, leading to significant inflamm
 ation modulation and plaque stabilization. The third study further advance
 s the system for multimodal diagnosis by developing an MRI/NIR dual-imagin
 g dendrimer nanoparticle to enable real-time visualization of uPAR-rich at
 herosclerotic plaques. Collectively\, these studies establish an adaptable
  uPA-mediated dendrimer platform capable of precise drug delivery and dise
 ase monitoring across oncology and cardiovascular applications\, offering 
 a clinically translatable strategy for precision nanomedicine.
LOCATION:
SUMMARY:Final Doctoral Defense for Hsin-Yin Chuang
URL;VALUE=URI:https://calendar.mst.edu/event/final-doctoral-defense-for-hsi
 n-yin-chuang
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