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DESCRIPTION:Vidit Singh\, a doctoral candidate in chemical engineering\, wi
 ll defend their dissertation titled “Lipid Based Nanoparticles for Gene and
  Drug Delivery in Inflammatory Diseases.” Their advisor\, Dr. Hu Yang\, is 
 Linda & Bipin Doshi Department Chair & Professor of Chemical & Biochemical 
 Engineering. The dissertation abstract is provided below.\n\nThis thesis ex
 plores lipid-based nanocarriers for targeted and non-targeted delivery of n
 ucleic acids and hydrophobic drugs in inflammatory diseases like cancer and
  cardiovascular disease models. In the first project\, cationic liposomes e
 ncapsulating the TLR3 agonist Poly I:C were developed for immunotherapy in 
 head and neck squamous cell carcinoma. These liposomes enhanced cytoplasmic
  delivery\, activated innate immune signaling\, and induced tumor regressio
 n in xenograft models.\n\nThe second project focused on liposomal encapsula
 tion of ML-098\, a hydrophobic RAB7 GTPase activator\, for pulmonary arteri
 al hypertension (PAH). Using a DMSO-assisted microfluidic method\, ML-098 l
 iposomes demonstrated 80% encapsulation\, selective endothelial uptake\, an
 d therapeutic efficacy in a rat Hx/Su model at significantly reduced dosing
  compared to free drug. The final project centered on Hemo-LNPs\, a novel m
 RNA delivery system for acute myeloid leukemia (AML). Formulated via a cust
 om Dual Inlet Vortex Jet Mixer and optimized through Taguchi DOE\, Hemo-LNP
 s achieved up to 99% transfection efficiency in AML cells. Delivery of TP53
  and DNMT3L mRNAs resulted in functional protein expression and reduced leu
 kemic proliferation\, outperforming commercial LNPs.\n\nTogether\, these st
 udies demonstrate the therapeutic potential of tailored lipid nanocarriers 
 for gene and drug delivery across diverse disease models.
DTEND:20250429T220000Z
DTSTAMP:20260310T094151Z
DTSTART:20250429T193000Z
GEO:37.952615;-91.775715
LOCATION:Bertelsmeyer Hall\, 110H
SEQUENCE:0
SUMMARY:Final Doctoral Defense for Vidit Singh
UID:tag:localist.com\,2008:EventInstance_49482458593304
URL:https://calendar.mst.edu/event/final-doctoral-defense-notification-for-
 vidit-singh
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